Drug expiration dating mixture
These drugs will then have to be reconstituted, or mixed with a liquid, called the diluent, before they can be administered.
Let's begin by looking at a sample label for a drug that needs to be reconstituted: The actual concentration you choose should be outlined in the drug order made by the physician, on the patient's chart and/or dictated by hospital policy as it applies to the patient's particular condition.
In the lab, tablets were dissolved, isotopes diluted, chromatography tests run.
Three times, the science crew tested and retested samples for listed active ingredients. Of the 14 drugs, 12 (or 86 percent) were present in concentrations at least 90 percent of the labeled amounts, which is the generally recognized minimum acceptable potency.
Generally, the authors warn, liquid drugs are not as stable as solid dosages, and should a liquid become cloudy, discolored, or show signs of precipitation, it should not be used.“Many drugs stored under reasonable conditions in their original unopened containers retain 90 percent of their potency for at least 5 years after the expiration date on the label, and sometimes much longer,” Cantrell and his colleagues travel an inspired path to scientific gold, arriving at a similar conclusion for their 2012 study.
In his wanderings, Cantrell “stumbled across” a box of drugs, all of which had expired 28 to 40 years prior.
The average additional time added to each drug was 66 months.
The team found two compounds (aspirin and amphetamine) in amounts of less than 90 percent; meanwhile, another ingredient (phenacetin) appeared at greater than 90 percent in one drug but less than 90 percent in another.“Given the potential cost-savings, we suggest the current practices of drug expiration dating be reconsidered,” Cantrell and his co-authors wrote in the conclusion.
The legal code adopted by the FDA also notes that manufacturers must account for storage conditions (and reconstitution conditions for certain drugs) in the expiration date.
As a result of FDA rules, then, you will find a date, usually following the letters ‘EXP,’ either printed on the label or stamped onto the bottle or carton of drugs you buy, and in other cases, crimped into the tube of certain ointments you purchase.
The short, safe answer is a simple “no.” However the truth of the matter is much more intricate, a lot more interesting, and requires a bit of knowledge about the Food and Drug Administration (FDA).
In the late 1970s, the FDA first began requiring expiration dates on both prescription and over-the-counter medications.“To assure that a drug product meets applicable standards of identity, strength, quality, and purity at the time of use, it shall bear an expiration date determined by appropriate stability testing,” reads the agency’s regulation.